Post-Doctoral Research Fellow - Chromatin Regulator and Immune Interaction in Blood Cancers, Lab of Jianping Li

Job Details The laboratory of Dr. Jianping Li (jianpinglilab.com) at the Sidney Kimmel Comprehensive Cancer Center (SKCCC) at Thomas Jefferson University (TJU) is seeking a highly motivated postdoctoral fellow to join our team on NIH/NCI-funded projects. Dr. Li’s lab focuses on the roles of chromatin regulators and immune interaction in blood cancers, especially in the initiation of acute lymphoblastic leukemia and lymphoma, relapse, chemotherapy resistance, and CNS infiltration.

We explore mutant chromatin regulators-driven phenotype and molecular mechanisms using cell lines, conditional mouse models, patient-derived xenografts (PDXs), and cutting-edge technologies such as CUT&RUN, ChIP-Seq, single-cell RNA-Seq, ATAC-Seq, Hi-C, proteomics, drug screening, flow cytometry and sorting, and CRISPR editing and screening (Nature Communications 2017, Cancer Discovery 2022, and Nature Chemical Biology 2024).

Job Description Eligibility Requirements : We are looking for highly motivated and enthusiastic postdoctoral fellows with a recent PhD or PhD/MD in molecular biology, T-cell immunology, cancer biology, or related fields. The candidate should have a strong interest in one of the following basic and translational research areas: chromatin regulation, cancer epigenetics, stem cell biology, immune interactions, CNS infiltration, and the development of targeted therapy.

We expect you to join our energetic group, enjoy the joy of research, and receive excellent training and career development to become an independent scientist. Experience in molecular cloning, CRISPR editing and screening, multi-omics sequencing analysis, flow cytometry, and sorting will be preferred. Qualified candidates should send their curriculum vitae and contact information of three professional references to Dr.

Jianping Li (Jianping.li@jefferson.edu). Institute : Sidney Kimmel Comprehensive Cancer Center (SKCCC) at Jefferson is recognized as high performing in cancer care by U.S. News & World Report and is designated a Comprehensive Cancer Center by the National Cancer Institute (NCI) for excellence in cancer care, prevention, and research. The NCI-designated SKCCC at TJU is home to national thought leaders across multiple cancer research disciplines and multi-institutional collaborations, announcing the expansion and deepening of hematologic malignancy research with the Blood Cancer Center of Excellence (BCCE).

Our faculty lead paradigm-shifting research into the initiation and progression of cancer, as well as resistance mechanisms and potential therapeutic targets. Here, researchers collaborate across multiple departments and specialties to address some of the most complex challenges in healthcare. Work Shift Workday Day (United States of America) Worker Sub Type Regular Employee Entity Thomas Jefferson University Primary Location Address 951 Locust Street, Philadelphia, Pennsylvania, United States of America Nationally ranked, Jefferson, which is principally located in the greater Philadelphia region, Lehigh Valley and Northeastern Pennsylvania and southern New Jersey, is reimagining health care and higher education to create unparalleled value.

Jefferson is more than 65,000 people strong, dedicated to providing the highest-quality, compassionate clinical care for patients; making our communities healthier and stronger; preparing tomorrow's professional leaders for 21st-century careers; and creating new knowledge through basic/programmatic, clinical and applied research. Thomas Jefferson University , home of Sidney Kimmel Medical College, Jefferson College of Nursing, and the Kanbar College of Design, Engineering and Commerce, dates back to 1824 and today comprises 10 colleges and three schools offering 200+ undergraduate and graduate programs to more than 8,300 students.

Jefferson Health , nationally ranked as one of the top 15 not-for-profit health care systems in the country and the largest provider in the Philadelphia and Lehigh Val