Senior Scientist

Senior Scientist – Biopharmaceutics Modelling & Simulation (PBPK/PBBM) An exciting opportunity has arisen for a Senior Scientist with expertise in Physiologically Based Pharmacokinetic (PBPK) and Physiologically Based Biopharmaceutics Modelling (PBBM) to join a growing pharmaceutical development team. This role will play a key part in applying mechanistic modelling and simulation approaches to support formulation development, predict clinical performance, and enable data-driven decision making across drug development programmes.

Working within multidisciplinary project teams, you will contribute to model-informed drug development strategies and support regulatory submissions through the application of advanced modelling techniques. Key Responsibilities Develop, verify and apply PBPK and PBBM models using platforms such as Simcyp, GastroPlus, PK-Sim or equivalent software. Support the prediction and assessment of oral absorption, bioavailability, food effects, formulation changes and virtual bioequivalence.

Conduct sensitivity analyses, model calibration, scenario testing and uncertainty assessments to support development decisions. Collaborate with scientists across formulation development, biopharmaceutics, clinical pharmacology and pharmacokinetics teams. Support the development of clinically relevant dissolution methods and in vitro-in vivo relationships where appropriate. Present modelling outcomes through technical reports, project team meetings, scientific publications and regulatory documentation.

Contribute to innovation within modelling and simulation, including automation, data science and emerging AI-enabled approaches. Requirements MSc or PhD in Pharmaceutical Sciences, Biopharmaceutics, Pharmacokinetics, Pharmacometrics, Chemical Engineering or a related scientific discipline. Demonstrated experience within PBPK, PBBM, pharmacometrics or model-informed drug development. Strong understanding of oral drug absorption, dissolution, permeability and pharmacokinetic principles.

Hands-on experience using modelling platforms such as Simcyp, GastroPlus, PK-Sim or similar tools. Ability to translate complex scientific data into practical development recommendations. Excellent scientific communication and stakeholder engagement skills. Evidence of scientific contribution through publications, presentations, technical reports or regulatory submissions. Desirable Experience Supporting regulatory submissions involving PBPK or PBBM analyses.

Virtual bioequivalence assessments and clinically relevant dissolution strategies. Programming experience with Python, R, MATLAB or similar scientific tools. Machine learning, AI or data science applications within pharmaceutical development. Experience working with challenging drug candidates, including poorly soluble compounds, enabling formulations, peptides or complex dosage forms.